OUTLINE THE EVIDENCE FOR SUPERANTIGEN PRODUCTION IN ISOLATES OF S. PSEUDINTERMEDIUS FROM CASES OF CANINE PYODERMA AND OTITIS

OUTLINE THE EVIDENCE FOR SUPERANTIGEN PRODUCTION IN ISOLATES OF S. PSEUDINTERMEDIUS FROM CASES OF CANINE PYODERMA AND OTITIS

1. Define the term superantigen (5 marks) and outline the evidence for superantigen
production in isolates of S. pseudintermedius from cases of canine pyoderma and
otitis (10 marks).
2. Briefly describe the structure and function of the three (3) major components of the
keratinocyte cytoskeleton. (15 marks)
3. In relation to type one Janus kinase receptors, briefly describe: (15 marks)
(A labelled diagram may be used to illustrate your answer.)
i. their structure
ii. how they are activated
iii. the intracellular molecular events that occur following activation
iv. the typical cellular responses that occur following activation
v. how they can be inhibited.
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Veterinary Dermatology Paper 1 Page 6 of 7
© 2015 The Australian and New Zealand College of Veterinary Scientists ABN 00 50 000894 208
4. Answer both parts of this question:
a) List how the following virulence factors contribute to the pathogenicity of
Staphylococcus sp.:
i. capsule/slime layer (3 marks)
ii. cell wall peptoglycan (3 marks)
iii. protein A (3 marks)
iv. teichoic acid. (1 mark)
b) For the following classes of antibiotics, list two (2) mechanisms by which
bacterial resistance develops:
i. fluoroquinolones (2.5 marks)
ii. beta-lactams. (2.5 marks)


 

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